Regulatory T-Cells in Pregnancy: Historical Perspective, State of the Art, and Burning Questions

P-154: Comparison between The Effect of 17-Bestradiol at Preovulatory and Pregnancy Levels for In Vitro Generation of Regulatory T Cells

Background: Naturally occurring CD4+CD25+ regulatory T cells (Treg) exert an important role in mediating maternal tolerance to the fetus during pregnancy. During pregnancy the elevated number of regulatory T cells (Tregs) correlates with 17-b oestradiol (E2) level. The role of maternal hormones in successful pregnancy is well known. Maternal hormones through re-engineering of the maternal immun...

Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion

Low 17β-estradiol Levels Are Better Inducers of Regulatory Conditioned T Cells In-Vitro

Background: 17β-estradiol (E2) has been known to modulate immune response. Recent studies indicate that E2 at pregnancy level plays a role in regulating T cell response. Objective: To investigate the optimum dose of E2 (from 10-9 to 10-7 M) in mediating the generation of regulatory T cells (Tregs), using naïve human CD4+ T cells from healthy women. Methods: Naïve peripheral T cells were purifie...

T Helper Cells Profile and CD4+CD25+Foxp3+Regulatory T Cells in Polycystic Ovary Syndrome

Background: Polycystic ovary syndrome (PCOS) is considered as the most common cause of female infertility that affects 4-10% of women in the reproductive age. Previous studies have shown the role of a balanced immune response in a successful pregnancy and fertility. Objective: To investigate the T helper cells type 1 (Th1) /Th2/Th17/Treg paradigms in peripheral blood of infertile PCOS compared ...

Rethinking of the Mathematical and Architectural Relation from the Perspective of the Algorithm

So far, many scholars have spoken of mathematical and architectural mergers. Different perspectives in this regard suggest that there are two general approaches paraphrastic and historians in most of these studies. But what has not been said about this aspect is common mental practices in mathematical science and architecture knowledge that affects the work of mathematicians and past architects...